Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 12052863 
Ostareck-Lederer A, et al. (2002) c-Src-mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs. Mol Cell Biol 22, 4535-43 12052863
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

Y72-p - hnRNP K (human)
Orthologous residues
hnRNP K (human): Y72‑p, hnRNP K iso2 (human): Y72‑p, hnRNP K (mouse): Y72‑p, hnRNP K iso2 (mouse): Y72‑p, hnRNP K iso4 (mouse): Y72‑p, hnRNP K (rat): Y72‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme, transfection of wild-type enzyme, transfection of inactive enzyme
 Comments:  based on Y72/225/230/234/236/380A mutant
Downstream Regulation
 Effect of modification (process):  translation, altered
 Comments:  based on Y72/225/230/234/236/380A mutant

Y225-p - hnRNP K (human)
Orthologous residues
hnRNP K (human): Y225‑p, hnRNP K iso2 (human): Y225‑p, hnRNP K (mouse): Y225‑p, hnRNP K iso2 (mouse): Y225‑p, hnRNP K iso4 (mouse): Y201‑p, hnRNP K (rat): Y225‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme, transfection of wild-type enzyme, transfection of inactive enzyme
 Comments:  based on Y72/225/230/234/236/380A mutant
Downstream Regulation
 Effect of modification (process):  translation, altered
 Comments:  based on Y72/225/230/234/236/380A mutant

Y230-p - hnRNP K (human)
Orthologous residues
hnRNP K (human): Y230‑p, hnRNP K iso2 (human): Y230‑p, hnRNP K (mouse): Y230‑p, hnRNP K iso2 (mouse): Y230‑p, hnRNP K iso4 (mouse): Y206‑p, hnRNP K (rat): Y230‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme, transfection of wild-type enzyme, transfection of inactive enzyme
 Comments:  based on Y72/225/230/234/236/380A mutant
Downstream Regulation
 Effect of modification (process):  translation, altered
 Comments:  based on Y72/225/230/234/236/380A mutant

Y234-p - hnRNP K (human)
Orthologous residues
hnRNP K (human): Y234‑p, hnRNP K iso2 (human): Y234‑p, hnRNP K (mouse): Y234‑p, hnRNP K iso2 (mouse): Y234‑p, hnRNP K iso4 (mouse): Y210‑p, hnRNP K (rat): Y234‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme, transfection of wild-type enzyme, transfection of inactive enzyme
 Comments:  based on Y72/225/230/234/236/380A mutant
Downstream Regulation
 Effect of modification (process):  translation, altered
 Comments:  based on Y72/225/230/234/236/380A mutant

Y236-p - hnRNP K (human)
Orthologous residues
hnRNP K (human): Y236‑p, hnRNP K iso2 (human): Y236‑p, hnRNP K (mouse): Y236‑p, hnRNP K iso2 (mouse): Y236‑p, hnRNP K iso4 (mouse): Y212‑p, hnRNP K (rat): Y236‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme, transfection of wild-type enzyme, transfection of inactive enzyme
 Comments:  based on Y72/225/230/234/236/380A mutant
Downstream Regulation
 Effect of modification (process):  translation, altered
 Comments:  based on Y72/225/230/234/236/380A mutant

Y380-p - hnRNP K (human)
Orthologous residues
hnRNP K (human): Y380‑p, hnRNP K iso2 (human): Y380‑p, hnRNP K (mouse): Y380‑p, hnRNP K iso2 (mouse): Y380‑p, hnRNP K iso4 (mouse): Y356‑p, hnRNP K (rat): Y380‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme, transfection of wild-type enzyme, transfection of inactive enzyme
 Comments:  based on Y72/225/230/234/236/380A mutant
Downstream Regulation
 Effect of modification (process):  translation, altered
 Comments:  based on Y72/225/230/234/236/380A mutant

Y419-p - Src (human)
Orthologous residues
Src (human): Y419‑p, Src (mouse): Y424‑p, Src iso2 (mouse): Y418‑p, Src (rat): Y419‑p, Src (chicken): Y416‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

Y530-p - Src (human)
Orthologous residues
Src (human): Y530‑p, Src (mouse): Y535‑p, Src iso2 (mouse): Y529‑p, Src (rat): Y530‑p, Src (chicken): Y527‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited


Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.