Curated Information
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Curated Information Page
PubMed Id: 11522789 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Li Z, Xi X, Du X (2001) A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3. J Biol Chem 276, 42226-32 11522789
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T185-p - ERK2 (human)
Orthologous residues
ERK2 (human): T185‑p, ERK2 (mouse): T183‑p, ERK2 (rat): T183‑p, ERK2 (chicken): T193‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Cellular systems studied:  cell lines
 Species studied:  hamster, human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
von Willebrand factor GPIbA (human), GPIbB (human), GPIX (human) increase
von Willebrand factor increase
anti-GPIbA von Willebrand factor GPIbA (human), GPIbB (human), GPIX (human) inhibit treatment-induced increase
PD98059 von Willebrand factor GPIbA (human), GPIbB (human), GPIX (human) inhibit treatment-induced increase
U0126 von Willebrand factor GPIbA (human), GPIbB (human), GPIX (human) inhibit treatment-induced increase
Rp-cGMP von Willebrand factor GPIbA (human), GPIbB (human), GPIX (human) inhibit treatment-induced increase
cGMP analog increase

Y187-p - ERK2 (human)
Orthologous residues
ERK2 (human): Y187‑p, ERK2 (mouse): Y185‑p, ERK2 (rat): Y185‑p, ERK2 (chicken): Y195‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Cellular systems studied:  cell lines
 Species studied:  hamster, human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
von Willebrand factor GPIbA (human), GPIbB (human), GPIX (human) increase
von Willebrand factor increase
anti-GPIbA von Willebrand factor GPIbA (human), GPIbB (human), GPIX (human) inhibit treatment-induced increase
PD98059 von Willebrand factor GPIbA (human), GPIbB (human), GPIX (human) inhibit treatment-induced increase
U0126 von Willebrand factor GPIbA (human), GPIbB (human), GPIX (human) inhibit treatment-induced increase
Rp-cGMP von Willebrand factor GPIbA (human), GPIbB (human), GPIX (human) inhibit treatment-induced increase
cGMP analog increase


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