Curated Information

Javascript is not enabled on this browser. This site will not work properly without Javascript.

Home

Curated Information Page

PubMed Id: 11516946

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Belham C, Comb MJ, Avruch J (2001) Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase. Curr Biol 11, 1155-67 11516946

T412-p - p70S6K (rat)

▲

Orthologous residues

p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Cellular systems studied: cell lines

Species studied: hamster

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	NEK6 (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	NEK6 (human)	transfection of inactive enzyme, transfection of wild-type enzyme
KINASE	PDK1 (rat)	transfection of wild-type enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
wortmannin				decrease
LY294002				decrease
insulin				increase

Downstream Regulation

Effect of modification (function): enzymatic activity, induced

Home \| Curator Login	With enhanced literature mining using Linguamatics I2E		Produced by 3rd Millennium \| Design by Digizyme
			©2003-2013 Cell Signaling Technology, Inc.