Curated Information
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Curated Information Page
PubMed Id: 12637568 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Sano H, et al. (2003) Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation. J Biol Chem 278, 14599-602 12637568
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S318-p - AS160 (human) ▲
Orthologous residues
AS160 (human): S318‑p, AS160 iso3 (human): ‑, AS160 (mouse): S324‑p, AS160 iso2 (mouse): S324‑p, AS160 (rat): S326‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

S341-p - AS160 (human) ▲
Orthologous residues
AS160 (human): S341‑p, AS160 iso3 (human): ‑, AS160 (mouse): S348‑p, AS160 iso2 (mouse): S348‑p, AS160 (rat): S350‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

S570-p - AS160 (human) ▲
Orthologous residues
AS160 (human): S570‑p, AS160 iso3 (human): S82‑p, AS160 (mouse): S577‑p, AS160 iso2 (mouse): S577‑p, AS160 (rat): S579‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

S588-p - AS160 (human) ▲
Orthologous residues
AS160 (human): S588‑p, AS160 iso3 (human): S100‑p, AS160 (mouse): S595‑p, AS160 iso2 (mouse): S595‑p, AS160 (rat): S597‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

T642-p - AS160 (human) ▲
Orthologous residues
AS160 (human): T642‑p, AS160 iso3 (human): T154‑p, AS160 (mouse): T649‑p, AS160 iso2 (mouse): T649‑p, AS160 (rat): T651‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase

S751-p - AS160 (human) ▲
Orthologous residues
AS160 (human): S751‑p, AS160 iso3 (human): S200‑p, AS160 (mouse): S758‑p, AS160 iso2 (mouse): S695‑p, AS160 (rat): S760‑p
Characterization
 Methods used to characterize site in vivo:  mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
insulin increase


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