Curated Information

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Curated Information Page

PubMed Id: 11606584

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Rodriguez R, et al. (2001) Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling. J Biol Chem 276, 47982-92 11606584

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y753-p - PLCG2 (human)

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Orthologous residues

PLCG2 (human): Y753‑p, PLCG2 (mouse): Y753‑p, PLCG2 (rat): Y753‑p

Characterization

Methods used to characterize site in vivo: mass spectrometry, mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: DT40 (B lymphocyte)

Cellular systems studied: cell lines

Species studied: chicken

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	Btk (human)
KINASE	Src (human)
KINASE	Fyn (human)
KINASE	Lck (human)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
H2O2				increase
anti-IgM				increase

Y759-p - PLCG2 (human)

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