|
Orthologous residues
|
|
HPK1 (human): Y381‑p, HPK1 (mouse): Y379‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site
|
|
Relevant cell lines - cell types - tissues:
Jurkat (T lymphocyte)
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
human
|
|
Downstream Regulation
|
|
Effect of modification (function):
enzymatic activity, induced, molecular association, regulation
|
|
Effect of modification (process):
transcription, altered
|
|
Modification regulates interactions with:
|
|
Interacting molecule
|
Interacting domains
|
Effect
|
Consequences (function)
|
Consequences (process)
|
Detection assays
|
|
SLP76 (human)
|
|
Induces
|
not reported
|
|
yeast two-hybrid, co-immunoprecipitation
|
|
BLNK (mouse)
|
|
Induces
|
not reported
|
|
yeast two-hybrid, co-immunoprecipitation
|
|
