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Orthologous residues
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arfaptin 2 (human): S260‑p, arfaptin 2 (mouse): S260‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site, phospho-antibody
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Relevant cell lines - cell types - tissues:
'neuron, cerebral cortical'-brain, 293 (epithelial) [arfaptin 2 (human)], 293T (epithelial), NG108-15 (neuron) [arfaptin 2 (human)]
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Cellular systems studied:
cell lines, primary cells
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Species studied:
human, rat
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Enzymes shown to modify site in vitro:
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Upstream Regulation
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Potential in vivo enzymes for site:
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Type
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Enzyme
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Evidence
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Notes
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KINASE
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Akt1 (human)
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transfection of wild-type enzyme
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Downstream Regulation
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Effect of modification (function):
intracellular localization
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Comments:
phosphorylation of site by Akt1 has a neuroprotective effect in Huntington's disease.
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