Curated Information
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Curated Information Page
PubMed Id: 18323454 
Dentin R, et al. (2008) Hepatic glucose sensing via the CREB coactivator CRTC2. Science 319, 1402-5 18323454
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T37-gl - TORC2 (mouse)
Orthologous residues
TORC2 (human): T37‑gl, TORC2 (mouse): T37‑gl, TORC2 (rat): T37‑gl
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human

S70-p - TORC2 (mouse)
Orthologous residues
TORC2 (human): S70‑p, TORC2 (mouse): S70‑p, TORC2 (rat): S70‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
glucosamine decrease
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 beta (human) Induces co-immunoprecipitation

S70-gl - TORC2 (mouse)
Orthologous residues
TORC2 (human): S70‑gl, TORC2 (mouse): S70‑gl, TORC2 (rat): S70‑gl
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
hyperglycemia increase
Downstream Regulation
 Effect of modification (function):  activity, induced, intracellular localization, molecular association, regulation, phosphorylation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 beta (human) Disrupts co-immunoprecipitation
 Comments:  inhibits phosphorylation of its own site

S127-gl - TORC2 (mouse)
Orthologous residues
TORC2 (human): S127‑gl, TORC2 (mouse): S127‑gl, TORC2 (rat): S127‑gl
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human

S128-gl - TORC2 (mouse)
Orthologous residues
TORC2 (human): S128‑gl, TORC2 (mouse): S128‑gl, TORC2 (rat): S128‑gl
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human

S171-p - TORC2 (mouse)
Orthologous residues
TORC2 (human): S171‑p, TORC2 (mouse): S171‑p, TORC2 (rat): S171‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
glucosamine decrease
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 beta (human) Induces co-immunoprecipitation

S171-gl - TORC2 (mouse)
Orthologous residues
TORC2 (human): S171‑gl, TORC2 (mouse): S171‑gl, TORC2 (rat): S171‑gl
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
hyperglycemia increase
Downstream Regulation
 Effect of modification (function):  activity, induced, intracellular localization, molecular association, regulation, phosphorylation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
14-3-3 beta (human) Disrupts co-immunoprecipitation
 Comments:  inhibits phosphorylation of its own site

S173-gl - TORC2 (mouse)
Orthologous residues
TORC2 (human): S173‑gl, TORC2 (mouse): S173‑gl, TORC2 (rat): S173‑gl
Characterization
 Methods used to characterize site in vivo mass spectrometry
 Disease tissue studied:  liver cancer
 Relevant cell lines - cell types - tissues:  HepG2 (hepatic)
 Cellular systems studied:  cell lines
 Species studied:  human


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