Curated Information
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Curated Information Page
PubMed Id: 19136967 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Liu Q, Busby JC, Molkentin JD (2009) Interaction between TAK1-TAB1-TAB2 and RCAN1-calcineurin defines a signalling nodal control point. Nat Cell Biol 11, 154-61 19136967
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S94-p - RCAN1 (rat)
Orthologous residues
RCAN1 (human): S149‑p, RCAN1 iso2 (human): S94‑p, RCAN1 iso3 (human): S68‑p, RCAN1 (mouse): S94‑p, RCAN1 (rat): S94‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE TAK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TAK1 (human) transfection of wild-type enzyme, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
serum increase
TGF-beta increase
phenylephrine increase
angiotensin 2 increase
endothelin increase
serum TAB2 (human) increase
TGF-beta TAB2 (human) increase
TAB1 (human) increase

S108-p - RCAN1 (rat)
Orthologous residues
RCAN1 (human): S163‑p, RCAN1 iso2 (human): S108‑p, RCAN1 iso3 (human): S82‑p, RCAN1 (mouse): S108‑p, RCAN1 (rat): S108‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  myocyte-heart
 Cellular systems studied:  primary cultured cells
 Species studied:  rat

S112-p - RCAN1 (rat)
Orthologous residues
RCAN1 (human): S167‑p, RCAN1 iso2 (human): S112‑p, RCAN1 iso3 (human): S86‑p, RCAN1 (mouse): S112‑p, RCAN1 (rat): S112‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  myocyte-heart
 Cellular systems studied:  primary cultured cells
 Species studied:  rat

S136-p - RCAN1 (rat)
Orthologous residues
RCAN1 (human): S191‑p, RCAN1 iso2 (human): S136‑p, RCAN1 iso3 (human): S110‑p, RCAN1 (mouse): S136‑p, RCAN1 (rat): S136‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE TAK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE TAK1 (human) transfection of wild-type enzyme, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
serum increase
TGF-beta increase
phenylephrine increase
angiotensin 2 increase
endothelin increase
serum TAB2 (human) increase
TGF-beta TAB2 (human) increase
TAB1 (human) increase

T187-p - TAK1 (rat)
Orthologous residues
TAK1 (human): T187‑p, TAK1 (mouse): T187‑p, TAK1 iso3 (mouse): T187‑p, TAK1 (rat): T187‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  myocyte-heart
 Cellular systems studied:  cell lines
 Species studied:  rat
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PPP3CA (human) genetic knockout/knockin of upstream enzyme


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