Curated Information
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Curated Information Page
PubMed Id: 11751967 
Gary-Gouy H, et al. (2002) CD5-negative regulation of B cell receptor signaling pathways originates from tyrosine residue Y429 outside an immunoreceptor tyrosine-based inhibitory motif. J Immunol 168, 232-9 11751967
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y453-p - CD5 (human)
Orthologous residues
CD5 (human): Y453‑p, CD5 (mouse): Y452‑p, CD5 (rat): Y449‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  A20 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  activity, induced
 Comments:  phosphorylation of Y453 is essential for CD5 functions, including inhibition of the BCR-induced calcium response, inhibition of Akt translocation, inhibition of IL-2 production.

Y465-p - CD5 (human)
Orthologous residues
CD5 (human): Y465‑p, CD5 (mouse): Y464‑p, CD5 (rat): Y461‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  A20 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  mouse


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