Curated Information
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Curated Information Page
PubMed Id: 19217427 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Dasgupta B, Milbrandt J (2009) AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development. Dev Cell 16, 256-70 19217427
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S804-p - Rb (mouse)
Orthologous residues
Rb (human): S811‑p, Rb (mouse): S804‑p, Rb (rat): S803‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'stem, neural'
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE AMPKA1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE AMPKA1 (mouse) pharmacological inhibitor of upstream enzyme, modification site within consensus motif, genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF, FGF1 increase
compound C EGF, FGF1 inhibit treatment-induced increase
glucose increase
compound C glucose inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  cell cycle regulation, cell growth, altered


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