Curated Information
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Curated Information Page
PubMed Id: 18838687 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Cereghetti GM, et al. (2008) Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. Proc Natl Acad Sci U S A 105, 15803-8 18838687
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S616-p - DRP1 (human) ▲
Orthologous residues
DRP1 (human): S616‑p, DRP1 iso3 (human): S579‑p, DRP1 (mouse): S622‑p, DRP1 iso3 (mouse): S579‑p, DRP1 iso6 (mouse): S592‑p, DRP1 (rat): S635‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human

S637-p - DRP1 (human) ▲
Orthologous residues
DRP1 (human): S637‑p, DRP1 iso3 (human): S600‑p, DRP1 (mouse): S643‑p, DRP1 iso3 (mouse): S600‑p, DRP1 iso6 (mouse): S613‑p, DRP1 (rat): S656‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
arachidonic acid decrease
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Comments:  dephosphorylated DRP1 translocates to mitochondreia


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