Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 15731757 
Loeys BL, et al. (2005) A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet 37, 275-81 15731757
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
Download Sites

S465-p - Smad2 (human)
Orthologous residues
Smad2 (human): S465‑p, Smad2 (mouse): S465‑p, Smad2 (rat): S465‑p, Smad2 (cow): S465‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  aorta, fibroblast-skin
 Cellular systems studied:  primary cells, tissue
 Species studied:  human
 Comments:  Marfan syndrome (MFS)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TGF-beta increase
Associated Diseases
Diseases: Alterations: Comments:
Marfan syndrome increased

S467-p - Smad2 (human)
Orthologous residues
Smad2 (human): S467‑p, Smad2 (mouse): S467‑p, Smad2 (rat): S467‑p, Smad2 (cow): S467‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  aorta, fibroblast-skin
 Cellular systems studied:  primary cells, tissue
 Species studied:  human
 Comments:  Marfan syndrome (MFS)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TGF-beta increase
Associated Diseases
Diseases: Alterations: Comments:
Marfan syndrome increased


Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.