Curated Information
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Curated Information Page
PubMed Id: 15665879 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Ji Y, Pang PT, Feng L, Lu B (2005) Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nat Neurosci 8, 164-72 15665879
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y515-p - TrkB (rat)
Orthologous residues
TrkB (human): Y516‑p, TrkB iso4 (human): Y532‑p, TrkB (mouse): Y515‑p, TrkB iso2 (mouse): , TrkB (rat): Y515‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  neuron-'brain, hippocampus'
 Cellular systems studied:  primary cultured cells
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
BDNF increase
cAMP analog BDNF augment treatment-induced increase
forskolin BDNF augment treatment-induced increase
isoproterenol BDNF augment treatment-induced increase
Rp-cAMPS BDNF inhibit treatment-induced increase
SKF38393 BDNF augment treatment-induced increase
cAMP analog increase
neurotrophin-3 increase

Y816-p - TrkB (rat)
Orthologous residues
TrkB (human): Y817‑p, TrkB iso4 (human): Y833‑p, TrkB (mouse): Y816‑p, TrkB iso2 (mouse): , TrkB (rat): Y816‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  neuron-'brain, hippocampus'
 Cellular systems studied:  primary cultured cells
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
BDNF increase
cAMP analog BDNF augment treatment-induced increase
forskolin BDNF augment treatment-induced increase
isoproterenol BDNF augment treatment-induced increase
Rp-cAMPS BDNF inhibit treatment-induced increase
SKF38393 BDNF augment treatment-induced increase
cAMP analog increase
neurotrophin-3 increase


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