Curated Information
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Curated Information Page
PubMed Id: 18952844 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Cai X, Liu X (2008) Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage. Proc Natl Acad Sci U S A 105, 16958-63 18952844
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T55-p - p53 (human)
Orthologous residues
p53 (human): T55‑p, p53 (mouse): , p53 iso2 (mouse): , p53 (rat): , p53 (rabbit): N54‑p, p53 (monkey): T55‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  bone cancer, lung cancer, non-small cell lung cancer, neuroblastoma
 Relevant cell lines - cell types - tissues:  IMR32 (neural crest), NCI-H1299 (pulmonary), U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
apigenin decrease
siRNA TAF1 (human) decrease
leptomycin B increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Effect of modification (process):  apoptosis, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
exportin 1 (human) Induces intracellular localization electrophoretic visualization, co-immunoprecipitation
 Comments:  export to cytoplasm


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