Curated Information
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Curated Information Page
PubMed Id: 10037602 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lu PJ, Zhou XZ, Shen M, Lu KP (1999) Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283, 1325-8 10037602
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T48-p - CDC25C (human)
Orthologous residues
CDC25C (human): T48‑p, CDC25C iso3 (human): T48‑p, CDC25C (mouse): S48‑p, CDC25C (frog): T48‑p
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein degradation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Pin1 (human) WW Induces molecular association, regulation in vitro, pull-down assay
NEDD4 (mouse) WW Induces molecular association, regulation in vitro, pull-down assay
 Comments:  WW domain binding initiates Pin1 and NEDD4 mediated protein degredation.

T67-p - CDC25C (human)
Orthologous residues
CDC25C (human): T67‑p, CDC25C iso3 (human): S66‑p, CDC25C (mouse): T66‑p, CDC25C (frog): T67‑p
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, protein degradation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
NEDD4 (mouse) WW Induces molecular association, regulation in vitro, pull-down assay
Pin1 (human) WW Induces molecular association, regulation in vitro, pull-down assay
 Comments:  WW domain binding initiates Pin1 and NEDD4 mediated protein degredation.

S16-p - Pin1 (human)
Orthologous residues
Pin1 (human): S16‑p, Pin1 (mouse): S16‑p, Pin1 (rat): S16‑p

Y23-p - Pin1 (human)
Orthologous residues
Pin1 (human): Y23‑p, Pin1 (mouse): Y23‑p, Pin1 (rat): Y23‑p
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Comments:  regulates association to phosphopeptides


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