Curated Information

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Curated Information Page

PubMed Id: 10037602

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Lu PJ, Zhou XZ, Shen M, Lu KP (1999) Function of WW domains as phosphoserine- or phosphothreonine-binding modules. Science 283, 1325-8 10037602

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T48-p - Cdc25C (human)

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Orthologous residues

Cdc25C (human): T48‑p, Cdc25C iso3 (human): T48‑p, Cdc25C (mouse): S48‑p, Cdc25C (frog): T48‑p

Downstream Regulation

Effect of modification (function): molecular association, regulation, protein degradation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
NEDD4 (mouse)	WW	Induces	molecular association, regulation		in vitro, pull-down assay
Pin1 (human)	WW	Induces	molecular association, regulation		in vitro, pull-down assay

Comments: WW domain binding initiates Pin1 and NEDD4 mediated protein degredation.

T67-p - Cdc25C (human)

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Orthologous residues

Cdc25C (human): T67‑p, Cdc25C iso3 (human): S66‑p, Cdc25C (mouse): T66‑p, Cdc25C (frog): T67‑p

Downstream Regulation

Effect of modification (function): molecular association, regulation, protein degradation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
NEDD4 (mouse)	WW	Induces	molecular association, regulation		in vitro, pull-down assay
Pin1 (human)	WW	Induces	molecular association, regulation		in vitro, pull-down assay

Comments: WW domain binding initiates Pin1 and NEDD4 mediated protein degredation.

S16-p - Pin1 (human)

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Orthologous residues

Pin1 (human): S16‑p, Pin1 (mouse): S16‑p, Pin1 (rat): S16‑p

Y23-p - Pin1 (human)

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Orthologous residues

Pin1 (human): Y23‑p, Pin1 (mouse): Y23‑p, Pin1 (rat): Y23‑p

Downstream Regulation

Effect of modification (function): molecular association, regulation

Comments: regulates association to phosphopeptides

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