Curated Information
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Curated Information Page
PubMed Id: 11334882 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Crouin C, et al. (2001) A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners. FEBS Lett 495, 148-53 11334882
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y266-p - Gab2 (human)
Orthologous residues
Gab2 (human): Y266‑p, Gab2 (mouse): Y263‑p, Gab2 (rat): Y263‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  Kit225 (T lymphocyte)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  human, yeast
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CrkL (human) Induces not reported yeast two-hybrid, co-immunoprecipitation

Y293-p - Gab2 (human)
Orthologous residues
Gab2 (human): Y293‑p, Gab2 (mouse): Y290‑p, Gab2 (rat): Y290‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  Kit225 (T lymphocyte)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  human, yeast
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CrkL (human) Induces not reported yeast two-hybrid, co-immunoprecipitation

Y452-p - Gab2 (human)
Orthologous residues
Gab2 (human): Y452‑p, Gab2 (mouse): Y441‑p, Gab2 (rat): Y441‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Cellular systems studied:  primary cultured cells
 Species studied:  yeast
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (human) Induces not reported yeast two-hybrid

Y476-p - Gab2 (human)
Orthologous residues
Gab2 (human): Y476‑p, Gab2 (mouse): Y465‑p, Gab2 (rat): Y465‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Cellular systems studied:  primary cultured cells
 Species studied:  yeast
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (human) Induces not reported yeast two-hybrid

Y584-p - Gab2 (human)
Orthologous residues
Gab2 (human): Y584‑p, Gab2 (mouse): Y573‑p, Gab2 (rat): Y573‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Cellular systems studied:  primary cultured cells
 Species studied:  yeast
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
PIK3R1 (human) Induces not reported yeast two-hybrid

Y614-p - Gab2 (human)
Orthologous residues
Gab2 (human): Y614‑p, Gab2 (mouse): Y603‑p, Gab2 (rat): Y603‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Cellular systems studied:  primary cultured cells
 Species studied:  yeast
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (human) Induces not reported yeast two-hybrid


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