Curated Information
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Curated Information Page
PubMed Id: 9525940 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Feshchenko EA, Langdon WY, Tsygankov AY (1998) Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells. J Biol Chem 273, 8323-31 9525940
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y700-p - Cbl (human)
Orthologous residues
Cbl (human): Y700‑p, Cbl (mouse): Y698‑p, Cbl (rat): Y699‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  COS (fibroblast), Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Fyn (human) co-immunoprecipitation
KINASE Syk (human) co-immunoprecipitation
KINASE Lck (human) co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vanadate increase
anti-CD3 increase

Y731-p - Cbl (human)
Orthologous residues
Cbl (human): Y731‑p, Cbl (mouse): Y737‑p, Cbl (rat): Y738‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  COS (fibroblast), Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Syk (human) co-immunoprecipitation
KINASE Fyn (human) co-immunoprecipitation
KINASE Lck (human) co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vanadate increase
anti-CD3 increase

Y774-p - Cbl (human)
Orthologous residues
Cbl (human): Y774‑p, Cbl (mouse): Y780‑p, Cbl (rat): Y781‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  COS (fibroblast), Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Fyn (human) co-immunoprecipitation
KINASE Lck (human) co-immunoprecipitation
KINASE Syk (human) co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
vanadate increase
anti-CD3 increase


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