Curated Information

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Curated Information Page

PubMed Id: 11145955

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Duan R, Xie W, Burghardt RC, Safe S (2001) Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. J Biol Chem 276, 11590-8 11145955

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S383-p - ELK1 (human)

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Orthologous residues

ELK1 (human): S383‑p, ELK1 (mouse): S384‑p, ELK1 (rat): S382‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site

Relevant cell lines - cell types - tissues: MCF-7 (breast cell)

Cellular systems studied: cell lines

Species studied: human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Effect
TGF-beta		increase
estrogen		increase
ICI 182,780	estrogen	inhibit treatment-induced increase
PD98059	estrogen	inhibit treatment-induced increase

Downstream Regulation

Effect of modification (process): transcription, altered

S389-p - ELK1 (human)

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