Curated Information
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Curated Information Page
PubMed Id: 11145955 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Duan R, Xie W, Burghardt RC, Safe S (2001) Estrogen receptor-mediated activation of the serum response element in MCF-7 cells through MAPK-dependent phosphorylation of Elk-1. J Biol Chem 276, 11590-8 11145955
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S383-p - ELK1 (human)
Orthologous residues
ELK1 (human): S383‑p, ELK1 (mouse): S384‑p, ELK1 (rat): S382‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TGF-beta increase
estrogen increase
ICI 182,780 estrogen inhibit treatment-induced increase
PD98059 estrogen inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  transcription, altered

S389-p - ELK1 (human)
Orthologous residues
ELK1 (human): S389‑p, ELK1 (mouse): S390‑p, ELK1 (rat): S388‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
TGF-beta increase
estrogen increase
ICI 182,780 estrogen inhibit treatment-induced increase
PD98059 estrogen inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  transcription, altered


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