Curated Information

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Curated Information Page

PubMed Id: 10635333

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Buck M, et al. (1999) Phosphorylation of rat serine 105 or mouse threonine 217 in C/EBP beta is required for hepatocyte proliferation induced by TGF alpha. Mol Cell 4, 1087-92 10635333

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T217-p - C/EBP-beta (mouse)

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Orthologous residues

C/EBP‑beta (human): T266‑p, C/EBP‑beta (mouse): T217‑p, C/EBP‑beta (rat): A218‑p, C/EBP‑beta (chicken): C249‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: hepatocyte-liver

Cellular systems studied: primary cells

Species studied: mouse, rat

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
TGF-alpha				increase

Downstream Regulation

Effect of modification (process): cell cycle regulation, cell growth, altered

S105-p - C/EBP-beta (rat)

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