Curated Information
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Curated Information Page
PubMed Id: 15316068 
Chen K, et al. (2004) Interaction between Dab1 and CrkII is promoted by Reelin signaling. J Cell Sci 117, 4527-36 15316068
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y198-p - DAB1 (human)
Orthologous residues
DAB1 (human): Y198‑p, DAB1 (mouse): Y198‑p, DAB1 iso2 (mouse): Y198‑p, DAB1 iso3 (mouse): Y198‑p, DAB1 (rat): Y198‑p, DAB1 (pig): Y198‑p, DAB1 iso1 (pig): , DAB1 (chicken): Y198‑p, DAB1 iso2 (chicken):
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain, 293T (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
reelin increase

Y220-p - DAB1 (human)
Orthologous residues
DAB1 (human): Y220‑p, DAB1 (mouse): Y220‑p, DAB1 iso2 (mouse): Y220‑p, DAB1 iso3 (mouse): Y220‑p, DAB1 (rat): Y220‑p, DAB1 (pig): Y220‑p, DAB1 iso1 (pig): , DAB1 (chicken): Y220‑p, DAB1 iso2 (chicken):
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain, 293T (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
reelin increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CRK (human) Induces electrophoretic visualization, co-immunoprecipitation

Y232-p - DAB1 (human)
Orthologous residues
DAB1 (human): Y232‑p, DAB1 (mouse): Y232‑p, DAB1 iso2 (mouse): Y232‑p, DAB1 iso3 (mouse): Y232‑p, DAB1 (rat): Y232‑p, DAB1 (pig): Y232‑p, DAB1 iso1 (pig): Y197‑p, DAB1 (chicken): Y232‑p, DAB1 iso2 (chicken): Y197‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, cerebellar granule'-brain, 293T (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
reelin increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
CRK (human) Induces electrophoretic visualization, co-immunoprecipitation

Y397-p - FAK (human)
Orthologous residues
FAK (human): Y397‑p, FAK iso2 (human): Y216‑p, FAK iso5 (human): Y397‑p, FAK (mouse): Y428‑p, FAK iso3 (mouse): Y397‑p, FAK iso4 (mouse): Y397‑p, FAK (rat): Y397‑p, FAK (chicken): Y397‑p, FAK iso5 (chicken):
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  NBT-II (bladder cell)
 Cellular systems studied:  cell lines
 Species studied:  human


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