Curated Information

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Curated Information Page

PubMed Id: 18757415

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Information from this record has been curated, but not yet edited in PhosphoSitePlus^® and may be incomplete.

Ogba N, et al. (2008) HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb. Cancer Res 68, 7015-24 18757415

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S1616-p - POLR2A (human)

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Orthologous residues

POLR2A (human): S1616‑p, POLR2A var1 (human): S1616‑p, POLR2A (mouse): S1616‑p, POLR2A (rat): S1616‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Disease tissue studied: breast cancer

Relevant cell lines - cell types - tissues: mammary gland [HEXIM1 (human), genetic knockin], MCF-7 (breast cell)

Cellular systems studied: cell lines

Species studied: human, mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Manipulated Protein	Effect
	HEXIM1 (human)	decrease
estrogen		increase
	HEXIM1 (human)	increase
estrogen	HEXIM1 (human)	decrease

Downstream Regulation

Effect of modification (function): enzymatic activity, induced, intracellular localization

Comments: Recruitment of hypophosphorylated serine 2 to coding region is Inhibited by HEXIM1 expression.

S1619-p - POLR2A (human)

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