Curated Information
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PubMed Id: 18772438 
Pan W, et al. (2008) Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation. Science 321, 1350-3 18772438
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T1479-p - LRP6 (human)
Orthologous residues
LRP6 (human): T1479‑p, LRP6 (mouse): T1479‑p, LRP6 (rat):
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PI(4,5)P2, Wnt3a increase requires PI(4,5)P2

S1490-p - LRP6 (human)
Orthologous residues
LRP6 (human): S1490‑p, LRP6 (mouse): S1490‑p, LRP6 (rat):
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
Wnt3a increase
siRNA Wnt3a PI4K2A (human) inhibit treatment-induced increase
siRNA Wnt3a PIP5K1B (human) inhibit treatment-induced increase
siRNA Wnt3a PIP5K1A (human) no effect upon treatment-induced increase
PI(4,5)P2 Wnt3a augment treatment-induced increase
siRNA Wnt3a FZD5 (human), FZD4 (human), FZD2 (human) inhibit treatment-induced increase
Wnt3a FZD5 (human) augment treatment-induced increase
siRNA Wnt3a DVL1 (human) inhibit treatment-induced increase


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