Curated Information
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Curated Information Page
PubMed Id: 15843398 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Warby SC, et al. (2005) Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo. Hum Mol Genet 14, 1569-77 15843398
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S419-p - Huntingtin (human) ▲
Orthologous residues
Huntingtin (human): S419‑p, Huntingtin (mouse): S398‑p, Huntingtin (rat): S389‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, cerebral cortical'-brain, 293 (epithelial), HeLa (cervical)
 Cellular systems studied:  primary cells
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE Akt1 (human)
PHOSPHATASE PPP2CA (human)

S473-p - Akt1 (mouse) ▲
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, cerebral cortical'-brain, 293 (epithelial)
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, mouse

S398-p - Huntingtin (mouse) ▲
Orthologous residues
Huntingtin (human): S419‑p, Huntingtin (mouse): S398‑p, Huntingtin (rat): S389‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, cerebral cortical'-brain
 Cellular systems studied:  primary cells
 Species studied:  human, mouse


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