Curated Information
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Curated Information Page
PubMed Id: 15677476 
Chen BP, et al. (2005) Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks. J Biol Chem 280, 14709-15 15677476
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S2056-p - DNAPK (human)
Orthologous residues
DNAPK (human): S2056‑p, DNAPK (mouse): S2053‑p, DNAPK (rat): S2051‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioma
 Relevant cell lines - cell types - tissues:  CHO (fibroblast), HSF (fibroblast), M059J (glial), M059K (glial)
 Cellular systems studied:  cell lines
 Species studied:  hamster, human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE DNAPK (human) transfection of wild-type enzyme, transfection of inactive enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
bleomycin increase
ionizing radiation increase
wortmannin ionizing radiation inhibit treatment-induced increase
etoposide increase
camptothecin increase
aphidicolin camptothecin inhibit treatment-induced increase
aphidicolin decrease

T2609-p - DNAPK (human)
Orthologous residues
DNAPK (human): T2609‑p, DNAPK (mouse): T2605‑p, DNAPK (rat): T2603‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  brain cancer, glioblastoma, glioma
 Relevant cell lines - cell types - tissues:  CHO (fibroblast), HSF (fibroblast), M059J (glial), M059K (glial)
 Cellular systems studied:  cell lines
 Species studied:  hamster, human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
camptothecin increase


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