Curated Information
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Curated Information Page
PubMed Id: 12101399 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Zhang L, Camerini V, Bender TP, Ravichandran KS (2002) A nonredundant role for the adapter protein Shc in thymic T cell development. Nat Immunol 3, 749-55 12101399
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y349-p - Shc1 (mouse) ▲
Orthologous residues
Shc1 (human): Y349‑p, Shc1 iso2 (human): Y239‑p, Shc1 iso3 (human): Y194‑p, Shc1 iso6 (human): Y349‑p, Shc1 iso7 (human): Y239‑p, Shc1 (mouse): Y349‑p, Shc1 iso2 (mouse): Y239‑p, Shc1 iso3 (mouse): Y194‑p, Shc1 (rat): Y349‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  T lymphocyte-thymus
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase
Downstream Regulation
 Effect of modification (function):  activation
 Effect of modification (process):  cell differentiation, altered

Y350-p - Shc1 (mouse) ▲
Orthologous residues
Shc1 (human): Y350‑p, Shc1 iso2 (human): Y240‑p, Shc1 iso3 (human): Y195‑p, Shc1 iso6 (human): Y350‑p, Shc1 iso7 (human): Y240‑p, Shc1 (mouse): Y350‑p, Shc1 iso2 (mouse): Y240‑p, Shc1 iso3 (mouse): Y195‑p, Shc1 (rat): Y350‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  T lymphocyte-thymus
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase
Downstream Regulation
 Effect of modification (function):  activation
 Effect of modification (process):  cell differentiation, altered

Y423-p - Shc1 (mouse) ▲
Orthologous residues
Shc1 (human): Y427‑p, Shc1 iso2 (human): Y317‑p, Shc1 iso3 (human): Y272‑p, Shc1 iso6 (human): Y428‑p, Shc1 iso7 (human): Y318‑p, Shc1 (mouse): Y423‑p, Shc1 iso2 (mouse): Y313‑p, Shc1 iso3 (mouse): Y268‑p, Shc1 (rat): Y423‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  T lymphocyte-thymus
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  activation
 Effect of modification (process):  cell differentiation, altered


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