Curated Information
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Curated Information Page
PubMed Id: 11896619 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Ekman S, et al. (2002) SHP-2 is involved in heterodimer specific loss of phosphorylation of Tyr771 in the PDGF beta-receptor. Oncogene 21, 1870-5 11896619
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y720-p - PDGFRa (human) ▲
Orthologous residues
PDGFRa (human): Y720‑p, PDGFRa (mouse): Y720‑p, PDGFRa (rat): Y719‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  pig
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (human) Induces

Y754-p - PDGFRa (human) ▲
Orthologous residues
PDGFRa (human): Y754‑p, PDGFRa (mouse): Y754‑p, PDGFRa (rat): Y753‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  pig
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (human) Induces

Y763-p - PDGFRb (human) ▲
Orthologous residues
PDGFRb (human): Y763‑p, PDGFRb (mouse): Y762‑p, PDGFRb (rat): Y762‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  pig
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (human) Induces

Y771-p - PDGFRb (human) ▲
Orthologous residues
PDGFRb (human): Y771‑p, PDGFRb (mouse): Y770‑p, PDGFRb (rat): Y770‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  pig
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE SHP-2 (human) co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
PDGF increase
vanadate PDGF augment treatment-induced increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
RASA1 (human) Induces

Y1009-p - PDGFRb (human) ▲
Orthologous residues
PDGFRb (human): Y1009‑p, PDGFRb (mouse): Y1008‑p, PDGFRb (rat): Y1008‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  PAE (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  pig
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
SHP-2 (human) Induces


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