Curated Information

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Curated Information Page

PubMed Id: 11804588

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Schmitt JM, Stork PJ (2002) PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1. Mol Cell 9, 85-94 11804588

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S17-p - Src (human)

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Orthologous residues

Src (human): S17‑p, Src (mouse): S17‑p, Src iso2 (mouse): S17‑p, Src (rat): S17‑p, Src (chicken): S17‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody

Relevant cell lines - cell types - tissues: 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], SYF (fibroblast)

Cellular systems studied: cell lines

Species studied: mouse

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PKACa (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	PKACa (human)	activation of upstream enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
forskolin				increase

Y419-p - Src (human)

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Orthologous residues

Src (human): Y419‑p, Src (mouse): Y424‑p, Src iso2 (mouse): Y418‑p, Src (rat): Y419‑p, Src (chicken): Y416‑p