Curated Information
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Curated Information Page
PubMed Id: 18760699 
Wang H, et al. (2008) FMRP acts as a key messenger for dopamine modulation in the forebrain. Neuron 59, 634-47 18760699
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S849-p - GluR1 (mouse)
Orthologous residues
GluR1 (human): S849‑p, GluR1 (mouse): S849‑p, GluR1 (rat): S849‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Comments:  prefrontal cortex
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SKF81297 no change compared to control
dihydrexidine no change compared to control
bromocriptine no change compared to control
quinpirole no change compared to control

S863-p - GluR1 (mouse)
Orthologous residues
GluR1 (human): S863‑p, GluR1 (mouse): S863‑p, GluR1 (rat): S863‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain
 Cellular systems studied:  primary cells
 Species studied:  mouse
 Comments:  prefrontal cortex
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SKF81297 increase
SCH 23390 SKF81297 inhibit treatment-induced increase
dihydrexidine increase
SCH 23390 dihydrexidine inhibit treatment-induced increase
bromocriptine decrease
quinpirole decrease
SKF81297 FMR1 (mouse) increase abrogated in FMR1 -/- mice
heparin SKF81297 FMR1 (mouse) no effect upon treatment-induced increase
peptide inhibitor SKF81297 FMR1 (mouse) no effect upon treatment-induced increase GRK2 peptide inhibitor


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