Curated Information
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PubMed Id: 12097497 
Heidinger V, et al. (2002) Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. J Neurosci 22, 5452-61 12097497
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y402-p - Pyk2 (mouse)
Orthologous residues
Pyk2 (human): Y402‑p, Pyk2 iso2 (human): Y402‑p, Pyk2 (mouse): Y402‑p, Pyk2 (rat): Y402‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 293 (epithelial)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  human, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DHPG increase
CPCCOEt DHPG inhibit treatment-induced increase
MPEP DHPG no effect upon treatment-induced increase
MK801 DHPG no effect upon treatment-induced increase
GF109203X DHPG no effect upon treatment-induced increase
PKCI 19-27 DHPG no effect upon treatment-induced increase
W-7 DHPG inhibit treatment-induced increase
calmidazolium DHPG inhibit treatment-induced increase
ophiobolin DHPG inhibit treatment-induced increase
CPCCOEt decrease
phorbol ester increase
GF109203X phorbol ester inhibit treatment-induced increase

Y424-p - Src (mouse)
Orthologous residues
Src (human): Y419‑p, Src (mouse): Y424‑p, Src iso2 (mouse): Y418‑p, Src (rat): Y419‑p, Src (chicken): Y416‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, cortical'-brain, 293 (epithelial)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  human, mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
DHPG increase
CPCCOEt DHPG inhibit treatment-induced increase
MPEP DHPG no effect upon treatment-induced increase
MK801 DHPG no effect upon treatment-induced increase
GF109203X DHPG no effect upon treatment-induced increase
PKCI 19-27 DHPG no effect upon treatment-induced increase
W-7 DHPG inhibit treatment-induced increase
calmidazolium DHPG inhibit treatment-induced increase
ophiobolin DHPG inhibit treatment-induced increase
CPCCOEt decrease
phorbol ester increase
GF109203X phorbol ester inhibit treatment-induced increase


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