Curated Information
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Curated Information Page
PubMed Id: 11825911 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Barry FA, Gibbins JM (2002) Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI. J Biol Chem 277, 12874-8 11825911
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T308-p - Akt1 (human)
Orthologous residues
Akt1 (human): T308‑p, Akt1 (mouse): T308‑p, Akt1 (rat): T308‑p, Akt1 (fruit fly): T423‑p, Akt1 (cow): T308‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  platelet-blood
 Cellular systems studied:  primary cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
collagen increase
LY294002 collagen inhibit treatment-induced increase
wortmannin collagen inhibit treatment-induced increase
thrombin increase
convulxin increase
LY294002 convulxin inhibit treatment-induced increase
wortmannin convulxin inhibit treatment-induced increase

S473-p - Akt1 (human)
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  platelet-blood
 Cellular systems studied:  primary cells
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
collagen increase
LY294002 collagen inhibit treatment-induced increase
wortmannin collagen inhibit treatment-induced increase
thrombin increase
convulxin increase
LY294002 convulxin inhibit treatment-induced increase
wortmannin convulxin inhibit treatment-induced increase


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