Curated Information
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Curated Information Page
PubMed Id: 10818091 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Evans DB, et al. (2000) Tau phosphorylation at serine 396 and serine 404 by human recombinant tau protein kinase II inhibits tau's ability to promote microtubule assembly. J Biol Chem 275, 24977-83 10818091
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S396-p - tau iso8 (human) ▲
Orthologous residues
tau (human): S713‑p, tau iso2 (human): S307‑p, tau iso3 (human): S271‑p, tau iso5 (human): S365‑p, tau iso6 (human): S338‑p, tau iso8 (human): S396‑p, tau (mouse): S688‑p, tau iso3 (mouse): S385‑p, tau iso7 (mouse): S345‑p, tau (rat): S707‑p, tau (cow): S403‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK5 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
TUBA1A (cow) Disrupts molecular association, regulation cytoskeletal reorganization in vitro
TUBB (cow) Disrupts molecular association, regulation cytoskeletal reorganization in vitro

S404-p - tau iso8 (human) ▲
Orthologous residues
tau (human): S721‑p, tau iso2 (human): S315‑p, tau iso3 (human): S279‑p, tau iso5 (human): S373‑p, tau iso6 (human): S346‑p, tau iso8 (human): S404‑p, tau (mouse): S696‑p, tau iso3 (mouse): S393‑p, tau iso7 (mouse): S353‑p, tau (rat): S715‑p, tau (cow): S411‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CDK5 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cytoskeletal reorganization
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
TUBA1A (cow) Disrupts molecular association, regulation cytoskeletal reorganization in vitro
TUBB (cow) Disrupts molecular association, regulation cytoskeletal reorganization in vitro


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