Curated Information
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Curated Information Page
PubMed Id: 11124251 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Giepmans BN, Hengeveld T, Postma FR, Moolenaar WH (2001) Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication. J Biol Chem 276, 8544-9 11124251
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Y265-p - GJA1 (rat)
Orthologous residues
GJA1 (human): Y265‑p, GJA1 (mouse): Y265‑p, GJA1 (rat): Y265‑p, GJA1 (rabbit): Y265‑p, GJA1 (hamster): Y265‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  COS (fibroblast), Rat1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Src (rat)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (rat) transfection of wild-type enzyme, transfection of inactive enzyme, transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell adhesion, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Src (rat) Induces co-immunoprecipitation


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