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Orthologous residues
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|
H3 (human): S11‑p, H3 (mouse): S11‑p, H3 iso2 (mouse): S11‑p, H3 iso3 (mouse): S11‑p, H3 (rat): S11‑p, H3 iso3 (rat): S11‑p, H3 (pig): S11‑p, H3 (chicken): S11‑p, H3 (cow): S11‑p
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Characterization
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|
Methods used to characterize site in vivo:
mutation of modification site, phospho-antibody
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|
Relevant cell lines - cell types - tissues:
293 (epithelial), 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], HeLa (cervical)
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Cellular systems studied:
cell lines
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|
Species studied:
human, mouse
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|
Enzymes shown to modify site in vitro:
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|
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Upstream Regulation
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|
Potential in vivo enzymes for site:
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|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
AurB (human)
|
transfection of inactive enzyme, co-immunoprecipitation, transfection of wild-type enzyme
|
|
|
KINASE
|
AurA (human)
|
transfection of inactive enzyme, co-immunoprecipitation, transfection of wild-type enzyme
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
intracellular localization
|
|
Effect of modification (process):
cell cycle regulation
|
