Curated Information
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Curated Information Page
PubMed Id: 19047460 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Daniel JA, et al. (2008) Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol 183, 777-83 19047460
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S367-p - ATM (mouse)
Orthologous residues
ATM (human): S367‑p, ATM (mouse): S367‑p, ATM (rat): S367‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  B lymphocyte-spleen
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Comments:  in triple S367/1899/1987A mutant ATM mice
Downstream Regulation
 Effect of modification (process):  chromatin organization, altered

S1899-p - ATM (mouse)
Orthologous residues
ATM (human): S1893‑p, ATM (mouse): S1899‑p, ATM (rat): S1900‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  B lymphocyte-spleen
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Comments:  in triple S367/1899/1987A mutant ATM mice
Downstream Regulation
 Effect of modification (process):  chromatin organization, altered

S1987-p - ATM (mouse)
Orthologous residues
ATM (human): S1981‑p, ATM (mouse): S1987‑p, ATM (rat): S1988‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  B lymphocyte-spleen
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
 Comments:  in triple S367/1899/1987A mutant ATM mice
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (mouse) pharmacological activator of upstream enzyme, genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
Downstream Regulation
 Effect of modification (process):  chromatin organization, altered

S15-p - p53 (mouse)
Orthologous residues
p53 (human): S15‑p, p53 (mouse): S15‑p, p53 iso2 (mouse): S18‑p, p53 (rat): S15‑p, p53 (rabbit): S15‑p, p53 (monkey): S15‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  B lymphocyte-spleen
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (mouse) pharmacological activator of upstream enzyme, genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase

S957-p - Smc1 (mouse)
Orthologous residues
Smc1 (human): S957‑p, Smc1 (mouse): S957‑p, Smc1 (rat): S957‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  B lymphocyte-spleen
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (mouse) pharmacological activator of upstream enzyme, genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase

S824-p - TIF1B (mouse)
Orthologous residues
TIF1B (human): S824‑p, TIF1B (mouse): S824‑p, TIF1B (rat): S825‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  B lymphocyte-spleen
 Cellular systems studied:  primary cultured cells
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE ATM (mouse) pharmacological activator of upstream enzyme, genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase


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