Curated Information
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Curated Information Page
PubMed Id: 12181566 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lindskog M, et al. (2002) Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature 418, 774-8 12181566
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T75-p - DARPP-32 (mouse)
Orthologous residues
DARPP‑32 (human): T75‑p, DARPP‑32 (mouse): T75‑p, DARPP‑32 (rat): T75‑p, DARPP‑32 (cow): T75‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, striatum'
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PPP2CA (mouse) pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
caffeine increase
roscovitine caffeine inhibit treatment-induced increase
SCH 58261 increase
CGS 21680 decrease
okadaic acid CGS 21680 inhibit treatment-induced decrease
okadaic acid increase


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