Curated Information
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Curated Information Page
PubMed Id: 15889144 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lukov GL, et al. (2005) Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly. EMBO J 24, 1965-75 15889144
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S18-p - PhLP (human) ▲
Orthologous residues
PhLP (human): S18‑p, PhLP (mouse): S18‑p, PhLP (rat): S18‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
G-gamma(2) (human) Induces co-immunoprecipitation
 Comments:  PhLP phosphorylation at S18-S20 induces association of G-gamma(2) with a G-beta(1)/PhLP complex. These PhLP phosphorylations are also required for normal G-beta/G-gamma dimer assembly.

S19-p - PhLP (human) ▲
Orthologous residues
PhLP (human): S19‑p, PhLP (mouse): T19‑p, PhLP (rat): T19‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
G-gamma(2) (human) Induces co-immunoprecipitation
 Comments:  PhLP phosphorylation at S18-S20 induces association of G-gamma(2) with a G-beta(1)/PhLP complex. These PhLP phosphorylations are also required for normal G-beta/G-gamma dimer assembly.

S20-p - PhLP (human) ▲
Orthologous residues
PhLP (human): S20‑p, PhLP (mouse): S20‑p, PhLP (rat): S20‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
G-gamma(2) (human) Induces co-immunoprecipitation
 Comments:  PhLP phosphorylation at S18-S20 induces association of G-gamma(2) with a G-beta(1)/PhLP complex. These PhLP phosphorylations are also required for normal G-beta/G-gamma dimer assembly.


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