|
Orthologous residues
|
|
14‑3‑3 eta (human): S59‑p, 14‑3‑3 eta (mouse): S59‑p, 14‑3‑3 eta (rat): S59‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
phospho-antibody
|
|
Relevant cell lines - cell types - tissues:
3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
|
|
Cellular systems studied:
cell lines
|
|
Species studied:
mouse
|
|
Enzymes shown to modify site in vitro:
|
|
|
|
Upstream Regulation
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
GF109203X
|
|
|
|
no change compared to control
|
|
|
DMS
|
|
|
|
increase
|
|
|
mPKI
|
|
|
|
decrease
|
|
|
H-89
|
|
|
|
decrease
|
|
|
cAMP analog
|
|
|
|
no change compared to control
|
|
|
