Curated Information
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Curated Information Page
PubMed Id: 15883165 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Ma Y, et al. (2005) Sphingosine activates protein kinase A type II by a novel cAMP-independent mechanism. J Biol Chem 280, 26011-7 15883165
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S59-p - 14-3-3 eta (mouse)
Orthologous residues
14‑3‑3 eta (human): S59‑p, 14‑3‑3 eta (mouse): S59‑p, 14‑3‑3 eta (rat): S59‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (cow)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GF109203X no change compared to control
DMS increase
mPKI decrease
H-89 decrease
cAMP analog no change compared to control


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