Curated Information
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Curated Information Page
PubMed Id: 15917297 
Krueger J, et al. (2005) Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation. Mol Biol Cell 16, 3552-61 15917297
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
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S104-p - PEA-15 (mouse)
Orthologous residues
PEA‑15 (human): S104‑p, PEA‑15 (mouse): S104‑p, PEA‑15 (rat): S104‑p, PEA‑15 (hamster): S104‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell cycle regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ERK2 (human) Disrupts intracellular localization cell adhesion, altered, transcription, altered co-immunoprecipitation, pull-down assay
ERK1 (human) Disrupts pull-down assay

S116-p - PEA-15 (mouse)
Orthologous residues
PEA‑15 (human): S116‑p, PEA‑15 (mouse): S116‑p, PEA‑15 (rat): S116‑p, PEA‑15 (hamster): S116‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  brain cancer, glioma, breast cancer
 Relevant cell lines - cell types - tissues:  CHO (fibroblast), mammary gland, MDA-MB231 (breast cell)
 Cellular systems studied:  cell lines, tissue
 Species studied:  hamster, human
 Comments:  Glioma CRL-1620 cells
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK2A1 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell cycle regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ERK2 (human) Disrupts intracellular localization cell adhesion, altered, transcription, altered co-immunoprecipitation, pull-down assay
ERK1 (human) Disrupts pull-down assay


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