Curated Information
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Curated Information Page
PubMed Id: 15917297 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Krueger J, et al. (2005) Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation. Mol Biol Cell 16, 3552-61 15917297
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S104-p - PEA-15 (mouse) ▲
Orthologous residues
PEA‑15 (human): S104‑p, PEA‑15 (mouse): S104‑p, PEA‑15 (rat): S104‑p, PEA‑15 (hamster): S104‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell cycle regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ERK1 (human) Disrupts pull-down assay
ERK2 (human) Disrupts intracellular localization cell adhesion, altered, transcription, altered co-immunoprecipitation, pull-down assay

S116-p - PEA-15 (mouse) ▲
Orthologous residues
PEA‑15 (human): S116‑p, PEA‑15 (mouse): S116‑p, PEA‑15 (rat): S116‑p, PEA‑15 (hamster): S116‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  brain cancer, glioma, breast cancer
 Relevant cell lines - cell types - tissues:  CHO (fibroblast), mammary gland, MDA-MB231 (breast cell)
 Cellular systems studied:  cell lines, tissue
 Species studied:  hamster, human
 Comments:  Glioma CRL-1620 cells
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CK2-A1 (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  cell cycle regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ERK1 (human) Disrupts pull-down assay
ERK2 (human) Disrupts intracellular localization cell adhesion, altered, transcription, altered co-immunoprecipitation, pull-down assay


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