Curated Information
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Curated Information Page
PubMed Id: 14662744 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Marsh HN, et al. (2003) SHP-1 negatively regulates neuronal survival by functioning as a TrkA phosphatase. J Cell Biol 163, 999-1010 14662744
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y496-p - TrkA (human) ▲
Orthologous residues
TrkA (human): Y496‑p, TrkA iso2 (human): Y490‑p, TrkA (mouse): Y499‑p, TrkA (rat): Y499‑p, TrkA iso2 (rat): Y493‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  SF9
 Cellular systems studied:  cell lines
 Species studied:  insect
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE SHP-1 (human) transfection of wild-type enzyme

Y680-p - TrkA (human) ▲
Orthologous residues
TrkA (human): Y680‑p, TrkA iso2 (human): Y674‑p, TrkA (mouse): Y683‑p, TrkA (rat): Y683‑p, TrkA iso2 (rat): Y677‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  SF9
 Cellular systems studied:  cell lines
 Species studied:  insect
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE SHP-1 (human) transfection of wild-type enzyme

Y681-p - TrkA (human) ▲
Orthologous residues
TrkA (human): Y681‑p, TrkA iso2 (human): Y675‑p, TrkA (mouse): Y684‑p, TrkA (rat): Y684‑p, TrkA iso2 (rat): Y678‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  SF9
 Cellular systems studied:  cell lines
 Species studied:  insect
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE SHP-1 (human) transfection of wild-type enzyme

S473-p - Akt1 (rat) ▲
Orthologous residues
Akt1 (human): S473‑p, Akt1 (mouse): S473‑p, Akt1 (rat): S473‑p, Akt1 (fruit fly): S586‑p, Akt1 (cow): S473‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, sympathetic', PC-12 (chromaffin)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NGF increase

Y683-p - TrkA (rat) ▲
Orthologous residues
TrkA (human): Y680‑p, TrkA iso2 (human): Y674‑p, TrkA (mouse): Y683‑p, TrkA (rat): Y683‑p, TrkA iso2 (rat): Y677‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, sympathetic', PC-12 (chromaffin)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  rat
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE SHP-1 (human) transfection of wild-type enzyme, co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NGF increase

Y684-p - TrkA (rat) ▲
Orthologous residues
TrkA (human): Y681‑p, TrkA iso2 (human): Y675‑p, TrkA (mouse): Y684‑p, TrkA (rat): Y684‑p, TrkA iso2 (rat): Y678‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  'neuron, sympathetic', PC-12 (chromaffin)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  rat
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE SHP-1 (human) transfection of wild-type enzyme, co-immunoprecipitation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
NGF increase


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