Curated Information
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Curated Information Page
PubMed Id: 12626521 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Oehrl W, Rubio I, Wetzker R (2003) Serine 338 phosphorylation is dispensable for activation of c-Raf1. J Biol Chem 278, 17819-26 12626521
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S338-p - RAF1 (human)
Orthologous residues
RAF1 (human): S338‑p, RAF1 (mouse): S338‑p, RAF1 (rat): S338‑p, RAF1 (chicken): S338‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  lymphoma
 Relevant cell lines - cell types - tissues:  U-937 (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
GTP-gammaS increase
wortmannin GTP-gammaS inhibit treatment-induced increase
genistein GTP-gammaS inhibit treatment-induced increase
phorbol ester increase
insulin increase
serum increase


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