Curated Information
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Curated Information Page
PubMed Id: 12612065 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Wang JM, Lai MZ, Yang-Yen HF (2003) Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway. Mol Cell Biol 23, 1896-909 12612065
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T180-p - p38-alpha (mouse) ▲
Orthologous residues
p38‑alpha (human): T180‑p, p38‑alpha iso2 (human): T180‑p, p38‑alpha (mouse): T180‑p, p38‑alpha (rat): T180‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor'), WEHI-3 (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IL-3 increase

S142-p - PU.1 (mouse) ▲
Orthologous residues
PU.1 (human): S140‑p, PU.1 (mouse): S142‑p, PU.1 (rat): S141‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, electrophoretic mobility shift, mutation of modification site
 Relevant cell lines - cell types - tissues:  BaF3 ('B lymphocyte, precursor'), WEHI-3 (myeloid)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anisomycin increase
IL-3 increase
SB203580 IL-3 inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  activation
 Effect of modification (process):  transcription, altered


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