Curated Information

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Curated Information Page

PubMed Id: 12198546

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Genoux D, et al. (2002) Protein phosphatase 1 is a molecular constraint on learning and memory. Nature 418, 970-5 12198546

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T286-p - CaMK2-alpha (mouse)

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Orthologous residues

CaMK2‑alpha (human): T286‑p, CaMK2‑alpha iso2 (human): T286‑p, CaMK2‑alpha (mouse): T286‑p, CaMK2‑alpha iso2 (mouse): ‑, CaMK2‑alpha (rat): T286‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'brain, cerebral cortex', 'brain, hippocampus'

Cellular systems studied: tissue

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
learning				increase
	learning	PPP1CA (mouse)		inhibit treatment-induced increase	enhanced in PP1CA knockout mice

S133-p - CREB (mouse)

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Orthologous residues

CREB (human): S133‑p, CREB iso2 (human): S119‑p, CREB (mouse): S133‑p, CREB (rat): S133‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'brain, cerebral cortex', 'brain, hippocampus'

Cellular systems studied: tissue

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
learning				increase
	learning	PPP1CA (mouse)		inhibit treatment-induced increase	enhanced in PP1CA knockout mice

S849-p - GluR1 (mouse)

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Orthologous residues

GluR1 (human): S849‑p, GluR1 (mouse): S849‑p, GluR1 (rat): S849‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 'brain, cerebral cortex', 'brain, hippocampus'

Cellular systems studied: tissue

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
learning				increase
	learning	PPP1CA (mouse)		inhibit treatment-induced increase	enhanced in PP1CA knockout mice

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