Curated Information
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Curated Information Page
PubMed Id: 13678583 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Bendjennat M, et al. (2003) UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair. Cell 114, 599-610 13678583
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y15-p - CDK2 (human) ▲
Orthologous residues
CDK2 (human): Y15‑p, CDK2 (mouse): Y15‑p, CDK2 (rat): Y15‑p
Characterization
 Methods used to characterize site in vivo:  phospho-antibody
 Relevant cell lines - cell types - tissues:  MEF (fibroblast) [IGF1R (mouse)], U2OS (bone cell) [GR (human)]
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
UV increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited
 Effect of modification (process):  cell cycle regulation

K16-u - p21Cip1 (human) ▲
Orthologous residues
p21Cip1 (human): K16‑u, p21Cip1 (mouse): K15‑u, p21Cip1 (dog): ‑
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  as a multiple K6R mutant
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination
 Comments:  UV-induced

K75-u - p21Cip1 (human) ▲
Orthologous residues
p21Cip1 (human): K75‑u, p21Cip1 (mouse): K74‑u, p21Cip1 (dog): K43‑u
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  as a multiple K6R mutant
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination
 Comments:  UV-induced

K141-u - p21Cip1 (human) ▲
Orthologous residues
p21Cip1 (human): K141‑u, p21Cip1 (mouse): K136‑u, p21Cip1 (dog): K109‑u
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  as a multiple K6R mutant
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination
 Comments:  UV-induced

K154-u - p21Cip1 (human) ▲
Orthologous residues
p21Cip1 (human): K154‑u, p21Cip1 (mouse): K149‑u, p21Cip1 (dog): K122‑u
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  as a multiple K6R mutant
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination
 Comments:  UV-induced

K161-u - p21Cip1 (human) ▲
Orthologous residues
p21Cip1 (human): K161‑u, p21Cip1 (mouse): K156‑u, p21Cip1 (dog): K129‑u
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  as a multiple K6R mutant
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination
 Comments:  UV-induced

K163-u - p21Cip1 (human) ▲
Orthologous residues
p21Cip1 (human): K163‑u, p21Cip1 (mouse): K158‑u, p21Cip1 (dog): K131‑u
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  as a multiple K6R mutant
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination
 Comments:  UV-induced


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