Curated Information
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
HomeAbout PhosphoSiteUsing PhosphoSiteCuration ProcessContact
NIH-logos NIGMS Logo NIAAA Logo NCI Logo NIH Logo
Curated Information Page
PubMed Id: 14623952 
Cammalleri M, et al. (2003) Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1. Proc Natl Acad Sci U S A 100, 14368-73 14623952
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Download Sites

T412-p - p70S6K (human)
Orthologous residues
p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, hippocampus', 'neuron, hippocampal'-brain
 Cellular systems studied:  primary cells, tissue
 Species studied:  rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
long-term potentiation increase
APV long-term potentiation inhibit treatment-induced increase
rapamycin long-term potentiation inhibit treatment-induced increase
LY294002 long-term potentiation inhibit treatment-induced increase
depolarization increase
APV depolarization inhibit treatment-induced increase
LY294002 depolarization inhibit treatment-induced increase
NBQX depolarization no effect upon treatment-induced increase
nifedipine depolarization no effect upon treatment-induced increase
rapamycin depolarization no effect upon treatment-induced increase
PD98059 depolarization no effect upon treatment-induced increase
glutamate increase
NMDA increase


Home  |  Curator Login With enhanced literature mining using Linguamatics I2E I2E Logo Produced by 3rd Millennium  |  Design by Digizyme
©2003-2013 Cell Signaling Technology, Inc.