Curated Information
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Curated Information Page
PubMed Id: 14511394 
Hawley SA, et al. (2003) Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2, 28 14511394
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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T183-p - AMPKA1 (human)
Orthologous residues
AMPKA1 (human): T183‑p, AMPKA1 (mouse): T183‑p, AMPKA1 (rat): T183‑p, AMPKA1 (fruit fly): T184‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LKB1 (human) genetic knockout/knockin of upstream enzyme, co-immunoprecipitation LKB1 acts in the complex with STRAD alpha/beta and MO25 alpha/beta
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phenformin increase
AICAR increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

T183-p - AMPKA1 (rat)
Orthologous residues
AMPKA1 (human): T183‑p, AMPKA1 (mouse): T183‑p, AMPKA1 (rat): T183‑p, AMPKA1 (fruit fly): T184‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE LKB1 (human)
 Comments:  LKB1 acts in the complex with STRAD alpha/beta and MO25 alpha/beta


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