Curated Information
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Curated Information Page
PubMed Id: 15833848 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Yang Z, et al. (2005) Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions. Cancer Res 65, 3179-84 15833848
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S246-p - Snail1 (human) ▲
Orthologous residues
Snail1 (human): S246‑p, Snail1 (mouse): S246‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial), MCF-7 (breast cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PAK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PAK1 (human) transfection of constitutively active enzyme, transfection of wild-type enzyme
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  transcription, altered


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