Curated Information
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Curated Information Page
PubMed Id: 12766170 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lock LS, Frigault MM, Saucier C, Park M (2003) Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain. J Biol Chem 278, 30083-90 12766170
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Y1349-p - Met (human)
Orthologous residues
Met (human): Y1349‑p, Met (mouse): Y1347‑p, Met (rat): Y1350‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  293T (epithelial), Rat1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human, rat
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Gab1 (human) Induces phosphorylation co-immunoprecipitation
 Comments:  The ability of the Y1349E/Y1356E mutant to bind and phosphorylate Gab1 also correlated with the ability of this mutant to transform fibroblasts.

Y1356-p - Met (human)
Orthologous residues
Met (human): Y1356‑p, Met (mouse): Y1354‑p, Met (rat): Y1357‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293T (epithelial), Rat1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  human, rat
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Gab1 (human) Induces phosphorylation co-immunoprecipitation
 Comments:  The ability of the Y1349E/Y1356E mutant to bind and phosphorylate Gab1 also correlated with the ability of this mutant to transform fibroblasts.


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