Curated Information
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Curated Information Page
PubMed Id: 12876286 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Ubeda M, Habener JF (2003) CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation. J Biol Chem 278, 40514-20 12876286
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S14-p - CHOP (human) ▲
Orthologous residues
CHOP (human): S14‑p, CHOP (mouse): S14‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CK2-A1 (human)
Downstream Regulation
 Effect of modification (function):  inhibition
 Effect of modification (process):  transcription, altered

S15-p - CHOP (human) ▲
Orthologous residues
CHOP (human): S15‑p, CHOP (mouse): S15‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CK2-A1 (human)
Downstream Regulation
 Effect of modification (function):  inhibition
 Effect of modification (process):  transcription, altered

S30-p - CHOP (human) ▲
Orthologous residues
CHOP (human): S30‑p, CHOP (mouse): S30‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CK2-A1 (human)
Downstream Regulation
 Effect of modification (function):  inhibition
 Effect of modification (process):  transcription, altered

S31-p - CHOP (human) ▲
Orthologous residues
CHOP (human): S31‑p, CHOP (mouse): S31‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mutation of modification site
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout], HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human, mouse
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CK2-A1 (human)
Downstream Regulation
 Effect of modification (function):  inhibition
 Effect of modification (process):  transcription, altered


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