Curated Information
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Curated Information Page
PubMed Id: 12538871 
Nishi A, et al. (2003) Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling. Proc Natl Acad Sci U S A 100, 1322-7 12538871
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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T34-p - DARPP-32 (mouse)
Orthologous residues
DARPP‑32 (human): T34‑p, DARPP‑32 (mouse): T34‑p, DARPP‑32 (rat): T34‑p, DARPP‑32 (cow): T34‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'neuron, neostriatal'-brain
 Cellular systems studied:  primary cells
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (mouse) pharmacological activator of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
t-ACPD increase
DHPG increase
MPEP DHPG inhibit treatment-induced increase
LY367385 DHPG no effect upon treatment-induced increase
8-(3-chlorostyryl) caffeine DHPG inhibit treatment-induced increase
ZM241385 DHPG inhibit treatment-induced increase
SCH 23390 DHPG no effect upon treatment-induced increase
cAMP analog DHPG no effect upon treatment-induced increase
IBMX DHPG augment treatment-induced increase
PD98059 DHPG inhibit treatment-induced increase
U0126 DHPG inhibit treatment-induced increase
8-(3-chlorostyryl) caffeine decrease
ZM241385 decrease
SCH 23390 decrease
CGS 21680 increase
MPEP CGS 21680 inhibit treatment-induced increase
SKF81297 increase
MPEP SKF81297 no effect upon treatment-induced increase
MPEP no change compared to control
forskolin increase
cAMP analog increase
IBMX increase


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